DENR (gene)

DENR
Identifiers
Aliases	DENR, DRP, DRP1, SMAP-3, density-regulated protein, density regulated re-initiation and release factor
External IDs	OMIM: 604550; MGI: 1915434; HomoloGene: 6275; GeneCards: DENR; OMA:DENR - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,771,064 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	124,066,898 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; visceral pleura; ; parietal pleura; ; endothelial cell; ; Brodmann area 23; ; palpebral conjunctiva; ; gingival epithelium; ; tibia; ; pars reticulata; ; hair follicle;
	Top expressed in
	primitive streak; ; somite; ; yolk sac; ; epiblast; ; seminal vesicula; ; abdominal wall; ; maxillary prominence; ; supraoptic nucleus; ; mandibular prominence; ; superior cervical ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; mRNA binding; translation initiation factor activity; ribosome binding; molecular function;
Cellular component	ribosome; translation initiation complex; cellular component;
Biological process	translational initiation; ribosome disassembly; protein biosynthesis; formation of translation preinitiation complex; translation reinitiation; IRES-dependent viral translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	8562
	68184
	ENSG00000139726
	ENSMUSG00000023106
	O43583
	Q9CQJ6
	NM_003677
	NM_026603
	NP_003668
	NP_080879
	Wikidata
View/Edit Human	View/Edit Mouse

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene. ^[5]

Function

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing the HER2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF2 and the initiator Met-tRNA_i^Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139726 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023106 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Density regulated re-initiation and release factor". Retrieved 2018-01-17.

Mazan-Mamczarz K, Gartenhaus RB (2007). "Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1". Cancer Genomics Proteomics. 4 (3): 233–9. PMID 17878526.
Lomakin IB, Stolboushkina EA, Vaidya AT, Zhao C, Garber MB, Dmitriev SE, Steitz TA (2017). "Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1". Cell Rep. 20 (3): 521–528. doi:10.1016/j.celrep.2017.06.025. PMC 5551485. PMID 28723557.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139726 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023106 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Density regulated re-initiation and release factor". Retrieved 2018-01-17.

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DENR (gene)

Function

See also

References

Further reading